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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">具有</font><font face="微软雅黑">EGFR19外显子缺失突变或21外显子L858R置换突变的局部晚期或转移性NSCLC成人患者的一线治疗。</font></span></span></span></span></span></span></span></span></span><br />
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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">既往经</font><font face="微软雅黑">EGFR-TKI治疗时或治疗后出现疾病进展，并且经检测确认存在EGFR-T790M突变阳性的局部晚期或转移性NSCLC成人患者的治疗。</font></span></span></span></span></span></span></span></span></span></p>

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<p align="justify" style="text-align:justify; margin:0pt 0pt 0.0001pt"><span style="font-size:10.5pt"><span style="text-justify:inter-ideograph"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><a href="http://www.india-drugstore.com/p/zhuanti_detail.php?id=78"><span style="color:#3498db;"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><strong><span style="background-color:#f1c40f;">Osimertinib（AZD9291）奥西替尼</span></strong></font></span></span></span></span></a><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"> 是一种口服的，有效的，不可逆的第三代EGFR-TKI，选择性靶向EGFR突变和T790M抗性突变，durvalumab（MEDI4736）是一种高亲和力人IgG1单克隆抗体，阻断PD- PD-1和CD80。</font></span></span></span></span></span></span></span></span></span></span></p>

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<p align="justify" style="text-align:justify; margin:0pt 0pt 0.0001pt"><span style="font-size:10.5pt"><span style="text-justify:inter-ideograph"><span style="font-family:Calibri"><b><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">奥西替尼禁忌症</font><font face="微软雅黑">:</font></span></span></span></span></span></span></span></b></span></span></span></p>

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<p align="justify" style="text-align:justify; margin:0pt 0pt 0.0001pt"><span style="font-size:10.5pt"><span style="text-justify:inter-ideograph"><span style="font-family:Calibri"><b><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">禁忌症</font><font face="微软雅黑">/警告/注意事项</font></span></span></span></span></span></span></span></b><br />
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<span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">间质性肺炎</font><font face="微软雅黑">/肺炎</font></span></span></span></span></span></span></span></span></span></span><br />
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<p align="justify" style="text-align:justify; margin:0pt 0pt 0.0001pt"><span style="font-size:10.5pt"><span style="text-justify:inter-ideograph"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">可能发生严重或致命的间质性肺病或肺炎</font></span></span></span></span></span></span></span></span></span></span><br />
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<p align="justify" style="text-align:justify; margin:0pt 0pt 0.0001pt"><span style="font-size:10.5pt"><span style="text-justify:inter-ideograph"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">暂时中断治疗，及时评估患者是否有任何呼吸道症状表明发生间质性肺病</font><font face="微软雅黑">;如果诊断得到确认，则永久停止</font></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" style="text-align:justify; margin:0pt 0pt 0.0001pt"><span style="font-size:10.5pt"><span style="text-justify:inter-ideograph"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><img alt="" src="../upload/6560601a10d39235433217.jpg" style="width: 200px; height: 81px;" /></font></span></span></span></span></span></span></span></span></span></span></p>

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