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<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="background:#fdfdfe"><span style="font-family:"><span style="color:#05073b">首先，尼达尼布被广泛用于治疗特发性肺纤维化（IPF）。这是一种慢性、进行性的间质性肺疾病，患者肺部结缔组织增加，导致瘢痕化和纤维化，进而引发呼吸困难、咳嗽、疲劳等症状。</span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"> </p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="background:#fdfdfe"><span style="font-family:"><span style="color:#05073b">尼达尼布通过抑制和阻断多个信号通路中的激酶活性，干扰瘢痕形成和纤维化过程，从而减缓疾病的进展，改善患者的生活质量和延缓肺功能下降速度</span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"> </p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="background:#fdfdfe"><span style="font-family:"><a href="http://www.india-drugstore.com/p/story_detail.php?id=506&art_cate_value=0&art_navid_value=2"><span style="color:#3498db;"><strong><span style="background-color:#f1c40f;">吡非尼酮</span></strong></span></a><span style="color:#05073b">主要用于轻、中度特发性肺纤维化的治疗。该药物具有抗炎、抗纤维化和抗氧化等多种作用，能够减少对多种刺激引起的炎症细胞积聚，减弱成纤维细胞的增殖和纤维化，从而起到抗纤维和抗炎作用</span></span></span></span><span style="font-variant-ligatures:normal; text-align:start; -webkit-text-stroke-width:0px"><span style="font-variant-caps:normal"><span style="orphans:2"><span style="widows:2"><span style="text-decoration-thickness:initial"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="float:none"><span style="word-spacing:0px">。</span></span></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"> </p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span sans-serif="" style="font-family:Calibri,"><span style="font-variant-ligatures:normal; text-align:start; -webkit-text-stroke-width:0px"><span style="font-variant-caps:normal"><span style="orphans:2"><span style="widows:2"><span style="text-decoration-thickness:initial"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="float:none"><span style="word-spacing:0px">吡非尼酮对肺纤维化有一定的疗效，可缓解患者因肺纤维化而引起的呼吸困难、胸闷、咳嗽等症状，也可抑制病情发展</span></span></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"> </p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="background:#fdfdfe"><span style="font-family:"><span style="color:#05073b">从已有的临床数据和不良反应报告来看，吡非尼酮在安全性方面可能略优于尼达尼布。例如，在排除死亡病例后，尼达尼布的严重不良事件发生率仍显著高于吡非尼酮</span></span></span></span><span style="font-variant-ligatures:normal; text-align:start; -webkit-text-stroke-width:0px"><span style="font-variant-caps:normal"><span style="orphans:2"><span style="widows:2"><span style="text-decoration-thickness:initial"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="float:none"><span style="word-spacing:0px">。此外，吡非尼酮在稳定性方面相较于尼达尼布更为稳定，停药率较少</span></span></span></span></span></span></span></span></span><span style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:宋体"><span style="color:#05073b"><span style="font-variant-ligatures:normal; text-align:start; -webkit-text-stroke-width:0px"><span style="font-variant-caps:normal"><span style="orphans:2"><span style="widows:2"><span style="text-decoration-thickness:initial"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="float:none"><span style="word-spacing:0px">。</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"> </p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:宋体"><span style="color:#05073b"><span style="font-variant-ligatures:normal; text-align:start; -webkit-text-stroke-width:0px"><span style="font-variant-caps:normal"><span style="orphans:2"><span style="widows:2"><span style="text-decoration-thickness:initial"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="float:none"><span style="word-spacing:0px"><img alt="" src="../upload/666bb33dd0e20028866262.jpg" style="width: 600px; height: 658px;" /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p>

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