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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">芦可替尼</font></span></span><span style="font-size:12.0000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">又叫</font></span></span><span style="font-size:12.0000pt"><span style="font-family:微软雅黑"><span style="color:#202020"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">鲁索替尼为全球首个治疗骨髓纤维化药物，被美国</font>FDA授予“孤儿药”资格。鲁索替尼的适应症范围可用于牛皮癣、白癜风、急性移植物抗宿主病等治疗在不断扩大。</span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"> </p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><a href="http://www.india-drugstore.com/p/drug_detail.php?navid=6&id=117"><strong><span style="color:#3498db;"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><span style="background-color:#f1c40f;">芦可替尼（</span></font></span></span></span></span></span></span></span><span style="color:#3498db;"><u><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="letter-spacing:0.0000pt"><span style="font-weight:bold"><span style="text-transform:none"><span style="text-decoration:underline"><span style="font-style:normal"><font face="微软雅黑"><span style="background-color:#f1c40f;">鲁索替尼</span></font></span></span></span></span></span></span></span></span></u></span></strong></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><a href="http://www.india-drugstore.com/p/drug_detail.php?navid=6&id=117"><strong>）</strong></a>是一种口服</font><font face="微软雅黑">JAK1和JAK2酪氨酸激酶抑制剂，于2012年8月获欧盟批准，用于治疗中级或高危骨髓纤维化，包括原发性骨髓纤维化，真性红细胞增多症后骨髓纤维化和原发性血小板增多症后骨髓纤维化。目前，鲁索替尼已获全球50多个国家批准，包括欧盟、加拿大和一些亚洲、拉丁美洲和南美洲国家。</font></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:3.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"> </p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:3.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="word-break:break-all"><span style="font-family:Calibri"><b><span class="16" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#333333"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">用法用量：</font></span></span></span></span></span></span></span></b></span></span></span></span></p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:3.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="word-break:break-all"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#333333"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">骨髓纤维化</font><font face="微软雅黑">:</font></span></span></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:3.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="word-break:break-all"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#333333"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">成人，每</font><font face="微软雅黑">12小时口服一次，每日两次，以此作为适应症。luxolitinib的用量一般在5mg到25mg之间，根据患者的情况应该增加或减少。</font></span></span></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:3.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"> </p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:3.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="word-break:break-all"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#333333"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">真性红细胞增多症</font><font face="微软雅黑">: 成人，每天一次，一次10 mg，每12小时口服一次，作为适应症。 应该根据病人的情况增加或减少，但一天两次，不应超过25毫克。</font></span></span></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:3.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="word-break:break-all"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#333333"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">真性红细胞红细胞增多症也是在适应症范围内的。</font></span></span></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:3.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="word-break:break-all"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#333333"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><img alt="" src="../upload/645c9926d79dc731804660.jpg" style="width: 338px; height: 600px;" /></font></span></span></span></span></span></span></span></span></span></span></span></p>

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