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<p class="p" style="margin-top:7.5000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="line-height:13.1500pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="font-family:微软雅黑"><a href="http://www.india-drugstore.com/p/wenda_detail.php?id=1936&art_cate_value=0&art_navid_value=2"><span style="color:#3498db;"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><strong>卡玛替尼</strong></font></span></span></span></span></a><span style="color:#333333"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">美国食品药品监督管理局（</font><font face="微软雅黑">FDA）批准了诺华的Tabrecta卡马替尼(capmatinib)治疗具有特定突变（跳过MET外显子14）的成年转移性NSCLC成人患者。约3％至4％的转移性NSCLC患者具有此突变（每年4,000至5,000美国患者）。</font></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:7.5000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"> </p>

<p class="p" style="margin-top:7.5000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="line-height:13.1500pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="font-family:微软雅黑"><span style="color:#202020"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">MET基因异常的NSCLC细胞即使不应该生长也可以分裂。这就是导致癌症形成并扩散到身体其他部位的原因。Tabrecta卡马替尼(capmatinib)靶向该基因及其使细胞生长的信号。通过停止该基因及其信号，癌细胞的生长可能会停止或减慢。</font></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:14.7000pt; margin-right:0.0000pt; margin-bottom:14.7000pt; margin-left:0.0000pt; margin:5pt 0pt; text-align:left"> </p>

<p class="p" style="margin-top:14.7000pt; margin-right:0.0000pt; margin-bottom:14.7000pt; margin-left:0.0000pt; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#121212"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">【不良反应】</font></span></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:14.7000pt; margin-right:0.0000pt; margin-bottom:14.7000pt; margin-left:0.0000pt; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#121212"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">卡马替尼可能会引起副作用，包括：呕吐、恶心、腹泻、便秘、肌肉、骨骼或背痛、食欲不振、疲倦和虚弱、头晕、手、脚、脚踝或小腿肿胀、皮疹。</font></span></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:7.5000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"> </p>

<p class="p" style="margin-top:7.5000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="line-height:13.1500pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#121212"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">【贮藏】</font></span></span></span></span></span></span></span><br />
<span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#121212"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">原包装存放于</font><font face="微软雅黑">20°C至25°C（68°F至77°F），允许短期储存在15°C至30°C（59°F至86°F）；注意防潮；首次打开瓶子6周后，请丢弃所有剩余的未使用的药片。</font></span></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:7.5000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="line-height:13.1500pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#121212"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><img alt="" src="../upload/64a3d9735b374966241395.jpg" style="width: 900px; height: 746px;" /></font></span></span></span></span></span></span></span></span></span></span></p>

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