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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><a href="http://www.india-drugstore.com/p/zhuanti_detail.php?id=1885"><strong><span style="color:#3498db;"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><span style="background-color:#f1c40f;">塞尔帕替尼</span></font></span></span></span></span></strong></a><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">是继今年</font>3月普拉替尼(pralsetinib,BLU-667)获批用于既往接受过含铂化疗的RET基因融合阳性的局部晚期或转移性NSCLC成人患者的治疗后有望第二个上市的RET 抑制剂，且适应症更广。</span></span></span></span></span></span></span><br />
<span style="font-size:5.5000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#666666"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"> </font></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">携带</font>RET突变的晚期或转移性甲状腺髓样癌成人和12岁及以上的儿童患者，以及需要系统性治疗和放射性碘治疗(如适用)难治的RET融合阳性的晚期或转移性</span></span></span></span></span></span></span><a href="https://www.cancer123.com/types/thyroid-cancer/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">甲状腺癌</font></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">成人和</font><font face="微软雅黑">12岁及以上的儿童患者</font></span></span></span></span></span></span></span><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">。</font></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"> </p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">塞尔帕替尼的用法用量</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">　　患者需携带</font><font face="微软雅黑">RET基因融合（NSCLC或</font></span></span></span></span></span></span></span><a href="https://www.cancer123.com/types/thyroid-cancer/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">甲状腺癌</font></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">）或</font><font face="微软雅黑">RET基因突变（MTC）</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">　　成人和</font><font face="微软雅黑">12岁及以上儿童患者的推荐剂量是基于体重的：</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">50kg以下：120mg,每日两次</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">50kg及以上：160mg,每日两次</font></span></span></span></span></span></span></span><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"> </p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">印度大药房如果购买到塞尔帕替尼？</font></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">可以买到的。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"> </p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><img alt="" src="../upload/653783e593419467824734.jpg" style="width: 405px; height: 600px;" /></font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"> </p>

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