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<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri,"sans-serif""><span style="color:#3498db;"><strong><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="background-color:#f1c40f;">卡马替尼（</span></span></span><span lang="EN-US" style="font-size:12.0pt"><span style="font-family:"PingFang-SC-Regular","serif""><span style="background-color:#f1c40f;">Capmatinib</span></span></span></strong></span><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#3498db;"><strong><span style="background-color:#f1c40f;">）</span></strong></span><span style="color:#05073b">是一种针对</span></span></span><span lang="EN-US" style="font-size:12.0pt"><span style="font-family:"PingFang-SC-Regular","serif""><span style="color:#05073b">MET</span></span></span><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b">抑制剂，主要用于治疗携带</span></span></span><span lang="EN-US" style="font-size:12.0pt"><span style="font-family:"PingFang-SC-Regular","serif""><span style="color:#05073b">MET</span></span></span><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b">基因扩增或</span></span></span><span lang="EN-US" style="font-size:12.0pt"><span style="font-family:"PingFang-SC-Regular","serif""><span style="color:#05073b">MET</span></span></span><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b">外显子</span></span></span><span lang="EN-US" style="font-size:12.0pt"><span style="font-family:"PingFang-SC-Regular","serif""><span style="color:#05073b">14</span></span></span><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b">跳跃突变的非小细胞肺癌患者。作为一种针对特定基因突变的药物，卡马替尼在临床试验中展现了一定的疗效。</span></span></span></span></span></p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"> </p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b">根据临床数据，卡马替尼在治疗</span></span></span><span lang="EN-US" style="font-size:12.0pt"><span style="font-family:"PingFang-SC-Regular","serif""><span style="color:#05073b">MET</span></span></span><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b">阳性非小细胞肺癌患者时，表现出了一定的客观缓解率（</span></span></span><span lang="EN-US" style="font-size:12.0pt"><span style="font-family:"PingFang-SC-Regular","serif""><span style="color:#05073b">ORR</span></span></span><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b">），这意味着一部分患者在使用卡马替尼后，其肿瘤体积会缩小或保持稳定。此外，卡马替尼还延长了部分患者的无进展生存期（</span></span></span><span lang="EN-US" style="font-size:12.0pt"><span style="font-family:"PingFang-SC-Regular","serif""><span style="color:#05073b">PFS</span></span></span><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b">），这意味着患者的病情进展得到了延缓。</span></span></span></span></span></p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"> </p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b">然而，需要注意的是，卡马替尼的疗效并非对所有患者都有效。不同患者的基因突变情况、身体状况以及肿瘤类型等因素都可能影响卡马替尼的疗效。因此，在使用卡马替尼前，患者需要进行基因检测，以确定是否适合使用该药物。</span></span></span></span></span></p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"> </p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt"><span style="font-family:"微软雅黑 Light","sans-serif""><span style="color:#05073b"><img alt="" src="../upload/65e197c1d04f1254513530.jpg" style="width: 182px; height: 200px;" /></span></span></span></span></span></p>

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