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<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri,"sans-serif""><a href="http://www.india-drugstore.com/p/wenda_detail.php?id=2093&art_cate_value=0&art_navid_value=2"><span style="color:#3498db;"><strong><span style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:宋体"><span style="background-color:#f1c40f;">索托拉西布（</span></span></span></span><span lang="EN-US" style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:"Segoe UI","sans-serif""><span style="background-color:#f1c40f;">Sotorasib</span></span></span></span></strong></span></a><span style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:宋体"><a href="http://www.india-drugstore.com/p/wenda_detail.php?id=2093&art_cate_value=0&art_navid_value=2"><span style="color:#3498db;"><strong><span style="background-color:#f1c40f;">）</span></strong></span></a><span style="color:#05073b">的作用机理主要围绕其特异性结合并抑制</span></span></span></span><span lang="EN-US" style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:"Segoe UI","sans-serif""><span style="color:#05073b">KRAS</span></span></span></span><span style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:宋体"><span style="color:#05073b">基因突变的激活状态。</span></span></span></span><span lang="EN-US" style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:"Segoe UI","sans-serif""><span style="color:#05073b">KRAS</span></span></span></span><span style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:宋体"><span style="color:#05073b">基因是一种在细胞内信号转导中起关键</span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"> </p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:宋体"><span style="color:#05073b">作用的基因，其编码的蛋白质能够调节细胞的生长、分化和凋亡。当</span></span></span></span><span lang="EN-US" style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:"Segoe UI","sans-serif""><span style="color:#05073b">KRAS</span></span></span></span><span style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:宋体"><span style="color:#05073b">基因发生突变时，会导致其编码的蛋白质持续处于激活状态，进</span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"> </p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:11.5pt"><span style="background:#fdfdfe"><span style="font-family:宋体"><span style="color:#05073b">而引发细胞不受控制的增殖和分化，最终可能形成肿瘤。</span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"> </p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="font-family:Calibri,"sans-serif""><span style="font-size:11.5pt"><span style="font-family:宋体"><span style="color:#05073b">首先，常见的副作用包括腹泻、肌肉骨骼疼痛、恶心、疲劳和肝毒性等。这些不良反应可能对患者的生活质量产生一定影响，但通常可以</span></span></span></span></span></span></p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"> </p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="font-family:Calibri,"sans-serif""><span style="font-size:11.5pt"><span style="font-family:宋体"><span style="color:#05073b">通过适当的医疗管理和剂量调整来控制。</span></span></span></span></span></span></p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"> </p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="font-family:Calibri,"sans-serif""><span style="font-size:11.5pt"><span style="font-family:宋体"><span style="color:#05073b">此外，索托拉西布还可能引起一些实验室检测异常，如淋巴细胞减少、血红蛋白降低、转氨酶升高等。这些变化需要密切监测，以便及时</span></span></span></span></span></span></p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"> </p>

<p align="left" style="margin-top:10.5pt; text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="font-family:Calibri,"sans-serif""><span style="font-size:11.5pt"><span style="font-family:宋体"><span style="color:#05073b">调整治疗方案。</span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"> </p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><img alt="" src="../upload/664717eab99c5471619818.jpg" style="width: 300px; height: 223px;" /></p>

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