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<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="vertical-align:baseline"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><a href="http://www.india-drugstore.com/p/zhuanti_detail.php?id=1860"><span style="color:#3498db;"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><strong>LUMAKRAS索托拉西布</strong></font></span></span></span></span></a><span style="color:#333333"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">是RAS GTPase家族的一种抑制剂，适用于治疗KRAS G12C突变的局部晚期或转移性非小细胞肺癌(NSCLC)(经FDA批准的检测确定)的成年患者，这些患者至少接受过一次既往全身治疗。</font></span></span></span></span></span></span></span></span></span></span></span></p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"> </p>

<p class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; margin:5pt 0pt; text-align:left"><span style="font-size:12pt"><span style="background:#ffffff"><span style="vertical-align:baseline"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#333333"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">在基于总体应答率</font><font face="微软雅黑">(ORR)和应答持续时间(DOR)的加速批准下批准该适应症。</font></span></span></span></span></span></span></span></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#666666"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">Lumakras为口服片剂，推荐剂量为每天一次(在同一时间)口服960 mg(8片，整片吞服</font></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"> </p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><b><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#666666"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">不良反应】</font></span></span></span></span></span></span></span></b></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#666666"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">最常见的不良反应</font><font face="微软雅黑">(≥ 20%)为腹泻、肌肉骨骼疼痛、恶心、疲劳、肝毒性和咳嗽。最常见的实验室检测异常(≥ 25%)为淋巴细胞减少、血红蛋白减少、天冬氨酸转氨酶增加、丙氨酸转氨酶增加、钙减少、碱性磷酸酶增加、尿蛋白增加和钠减少。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#666666"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">储存在</font><font face="微软雅黑">20℃至25℃(68℉至77℉)的温度下。允许从15℃到30℃(59℉到86℉)的偏移[参见美国药典控制的室温]。</font></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#666666"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><img alt="" src="../upload/64a7c4f79dbff271997842.jpg" style="width: 900px; height: 669px;" /></font></span></span></span></span></span></span></span></span></span></p>

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