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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><a href="http://www.india-drugstore.com/p/zhuanti_detail.php?id=1857"><span style="color:#3498db;"><strong><span class="15" style="font-size:12.0000pt"><span style="font-family:微软雅黑"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">卡博替尼（</font><font face="微软雅黑">Cabozantinib）</font></span></span></span></span></span></span></strong></span></a><span style="font-size:12.0000pt"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">由美国</font><font face="微软雅黑">Exelixis生物制药公司研发，是一个多靶点的广谱抗癌药，能抑制的靶点包括：MET、VEGFR1/2/3、ROS1、RET、AXL、NTRK、KIT等至少9个。 目前，卡博替尼已经在</font></span></span></span></span></span></span></span><span class="15" style="font-size:12.0000pt"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">肾癌、甲状腺癌、肝癌、软组织肉瘤、非小细胞肺癌、前列腺癌、乳腺癌、卵巢癌、肠癌</font></span></span></span></span></span></span></span><span style="font-size:12.0000pt"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">等多种实体瘤中，证实了较好的治疗效果</font></span></span></span></span></span></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">卡博替尼是肾癌患者的一线治疗药物</font><font face="微软雅黑">;适用于治疗进展期、转移性的甲状腺髓样癌(MTC)患者;伴有C-met扩增的晚期非小细胞肺癌(NSCLC)患者; 接受过索拉非尼治疗的肝细胞癌(HCC)患者的二线治疗。</font></span></span></span></span></span></span></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">卡博替尼剂量：</font></span></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">用于治疗转移性甲状腺髓样癌的推荐剂量为每日</font><font face="微软雅黑">140 mg，用于晚期非小细胞肺癌、肝癌、肾癌的推荐剂量为每日60mg。</font></span></span></span></span></span></span></span></span></span></span></p>

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