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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><strong><a href="http://www.india-drugstore.com/p/drug_detail.php?navid=6&id=47"><span style="color:#3498db;"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><span style="background-color:#f1c40f;">劳拉替尼</span></font></span></span></span></span></span></span></span></span></a></strong><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">于</font><font face="微软雅黑">2018年11月02日获FDA批准上市，用于治疗接受</font></span></span></span></span></span></span></span></span><a href="https://www.cancer123.com/drugs/Crizotinib/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">克唑替尼</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">和至少一种其它</font><font face="微软雅黑">ALK抑制剂治疗之后疾病发生恶化，或接受</font></span></span></span></span></span></span></span></span><a href="https://www.cancer123.com/drugs/Alectinib/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">阿来替尼</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">（</font><font face="微软雅黑">alectinib）或</font></span></span></span></span></span></span></span></span><a href="https://www.cancer123.com/drugs/Ceritinib/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">色瑞替尼</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">（</font><font face="微软雅黑">ceritinib）作为第一个ALK抑制剂治疗但疾病恶化的ALK阳性转移性非小细胞</font></span></span></span></span></span></span></span></span><a href="https://www.cancer123.com/types/lung-cancer/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">肺癌</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">（</font><font face="微软雅黑">NSCLC）患者。</font></span></span></span></span></span></span></span></span></span></span></p>

<h1 style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:left"> </h1>

<h1 style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:left"><span style="font-size:24pt"><span style="background:#ffffff"><span style="font-family:宋体"><span style="font-weight:bold"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.4000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">劳拉替尼</font><font face="微软雅黑">(Lorlatinib)</font></span></span></span></span></span></span></span></span><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">洛拉替</font></span></span></span></span></span></span></span></span><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">尼</font></span></span></span></span></span></span></span></span><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.4000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">用于治疗接受克唑替尼和至少一种其它</font><font face="微软雅黑">ALK抑制剂治疗之后疾病发生恶化，或接受阿来替尼（alectinib）或色瑞替尼（ceritinib）作为第一个ALK抑制剂治疗但疾病恶化的ALK阳性转移性非小细胞肺癌（NSCLC）患者。</font></span></span></span></span></span></span></span></span></span></span></span></span></h1>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">　</font></span></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">对于脑转移的预防和缓解，</font></span></span></span></span></span></span></span></span><a href="https://www.cancer123.com/drugs/Lorlatinib"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">劳拉替尼</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">也表现出了显著优势。在</font><font face="微软雅黑">12个月时，</font></span></span></span></span></span></span></span></span><a href="https://www.cancer123.com/drugs/Lorlatinib"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">劳拉替尼</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">组无颅内疾病进展的生存率为</font><font face="微软雅黑">96%，而</font></span></span></span></span></span></span></span></span><a href="https://www.cancer123.com/drugs/Crizotinib/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">克唑替尼</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">治疗组这一比例为</font><font face="微软雅黑">60%。</font></span></span></span></span></span></span></span></span><a href="https://www.cancer123.com/drugs/Lorlatinib"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">劳拉替尼</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">将颅内疾病进展或死亡的风险降低</font><font face="微软雅黑">93%！</font></span></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><img alt="" src="../upload/64d0b4205a44a205070866.jpg" style="width: 600px; height: 600px;" /></font></span></span></span></span></span></span></span></span></span></span></p>

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