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<h1 style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:left"><span style="font-size:24pt"><span style="background:#ffffff"><span style="font-family:宋体"><span style="font-weight:bold"><a href="http://www.india-drugstore.com/p/wenda_detail.php?id=2008&art_cate_value=0&art_navid_value=2"><span style="color:#3498db;"><strong><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><span style="background-color:#f1c40f;">Selpercatinib 塞普替尼，塞尔帕替尼</span></font></span></span></span></span></span></span></span></strong></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">用于治疗</font><font face="微软雅黑">:</font></span></span></span></span></span></span></span></span></span></span></span></span></h1>

<ol>
	<li style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:left"><span style="font-size:24pt"><span style="background:#ffffff"><span style="font-family:宋体"><span style="font-weight:bold"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">转移性</font><font face="微软雅黑">RET融合阳性的非小细胞肺癌(NSCLC)成人患者;</font></span></span></span></span></span></span></span></span></span></span></span></span></li>
	<li style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:left"><span style="font-size:24pt"><span style="background:#ffffff"><span style="font-family:宋体"><span style="font-weight:bold"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">需要全身治疗(需要口服或注射)的晚期或转移性RET突变甲状腺髓样癌的成人和12岁以上儿童患者;</font></span></span></span></span></span></span></span></span></span></span></span></span></li>
	<li style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:left"><span style="font-size:24pt"><span style="background:#ffffff"><span style="font-family:宋体"><span style="font-weight:bold"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">需要全身治疗而且放射碘治疗抵抗的晚期或转移性RET融合阳性甲状腺癌成人和12岁以上儿童患者。</font></span></span></span></span></span></span></span></span></span></span></span></span></li>
</ol>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">塞尔帕替尼的服用需要根据体重来区别使用，具体方法为患者体重少于</font>50kg，塞尔帕替尼剂量为120mg，患者体重50kg及以上，塞尔帕替尼剂量为160mg。每12小时口服一次，每天2次。塞尔帕替尼可以一直服用到患者的疾病有新的进展，或者患者出现了不可接受的毒性。</span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">塞尔帕替尼的不良反应：</font></span></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">　　最常见的不良反应（</font><font face="微软雅黑">≥25%）：</font></span></span></span></span></span></span></span></span><a href="http://www.zhys.com/shicai/127.html"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">天冬</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">氨酸转氨酶</font><font face="微软雅黑">(AST)、谷丙转氨酶(ALT)、</font></span></span></span></span></span></span></span></span><a href="http://www.zhys.com/shicai/622.html"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">葡萄</font></span></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">糖增加，白细胞、白蛋白减少、钙减少，口干，腹泻，肌酐增加，碱性磷酸酶增加，高血压，疲劳，水肿，血小板减少，总胆固醇增加，皮疹，钠减少和便秘。</font></span></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:12.0000pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:normal"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><img alt="" src="../upload/6549f53fd26e6137537583.jpg" style="width: 405px; height: 600px;" /></font></span></span></span></span></span></span></span></span></span></span></span></span></span></p>

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