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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">针对</font>KRAS基因突变的首款靶向药物</span></span></span></span><a href="http://www.india-drugstore.com/p/zhuanti_detail.php?id=1955"><span style="color:#3498db;"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><strong><span style="background-color:#f1c40f;">Lumakras（</span></strong></span></span></span></span></a></span></span></span><a href="http://www.india-drugstore.com/p/zhuanti_detail.php?id=1955"><strong><span style="color:#3498db;"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><span style="background-color:#f1c40f;">Sotorasib</span></font></span></span></span></span></span></span></span></strong></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><a href="http://www.india-drugstore.com/p/zhuanti_detail.php?id=1955"><span style="color:#3498db;"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><strong><font face="微软雅黑"><span style="background-color:#f1c40f;">），代号为</span></font></strong><font face="微软雅黑"><strong><span style="background-color:#f1c40f;">AMG510，中文名索托拉西布</span></strong></font></span></span></span></span></a><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">。索托拉西布是由美国安进公司研发，是全球首个获批的靶向KRAS突变的抗肿瘤药物。同时是一种新型的、首创的小分子KRAS抑制剂，通过将KRAS锁定在无活性的GDP结合状态、能够特异性且不可逆的抑制KRAS.</font></span></span></span></span></span></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">适用于治疗</font>KRAS G12C突变的局部晚期或转移性非小细胞肺癌(NSCLC)(经FDA批准的检测确定)的成年患者，这些患者至少接受过一次既往全身治疗</span></span></span></span></span></span></span><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">。</font></span></span></span></span></span></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><a href="https://www.cancer123.com/drugs/206/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">Sotorasib</font></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">（索托拉西布）是成功靶向</font><font face="微软雅黑">KRAS并进入人体临床开发的首批小分子抑制剂之一，可靶向抑制携带G12C突变的KRAS蛋白。索托拉西布通过将G12C突变KRAS蛋白锁定在一种非激活GDP结合状态来特异性地和不可逆地抑制其促增殖活性</font></span></span></span></span></span></span></span><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">。</font></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><img alt="" src="../upload/652371335eaec339735654.jpg" style="width: 800px; height: 595px;" /></font></span></span></span></span></span></span></span></span></span></p>

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