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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><b><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="font-weight:bold"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">KRAS G12C突变</font></span></span></span></span></span></span></span></span></b><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">是非小细胞肺癌</font><font face="微软雅黑">KRAS突变当中最常见的亚型，这部分患者的治疗，长期以来依赖化疗、免疫治疗以及疗效并不理想的靶向治疗。KRAS抑制剂的问世，让这部分患者，尤其是已经尝试过了一线化疗的患者，迎来了全新的治疗选择。</font></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"> </p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><a href="http://www.india-drugstore.com/p/zhuanti_detail.php?id=1955"><span style="color:#3498db;"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><strong>索托拉西布</strong></font></span></span></span></span></a><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">治疗期间最常见的副作用包括腹泻、肌肉骨骼疼痛、恶心、疲劳、肝损伤和咳嗽。根据美国</font><font face="微软雅黑">FDA 的规定，如果患者治疗期间出现间质性肺病的症状，应停用索托拉西布；如果确诊为间质性肺病，则应永久停用索托拉西布.在治疗开始前研究者应监测患者肝功能，如果出现肝损伤，应停用索托拉西布、减少剂量或永久停药。</font></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"> </p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">安进已获得美国食品和药物管理局</font> <font face="微软雅黑">(FDA) 的批准，其索托拉西布 (</font></span></span></span></span></span></span></span><a href="https://www.cancer123.com/drugs/206/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">Sotorasib</font></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">) 用于治疗患有 KRAS G12C 突变的局部晚期或转移性非小细胞</font></span></span></span></span></span></span></span><a href="https://www.cancer123.com/types/lung-cancer/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">肺癌</font></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"> (NSCLC) 的成人。索托拉西布(</font></span></span></span></span></span></span></span><a href="https://www.cancer123.com/drugs/206/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">Sotorasib</font></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">)适用于已接受过一种或多种全身治疗的人的 FDA 批准的测试检测到的</font></span></span></span></span></span></span></span><a href="https://www.cancer123.com/types/lung-cancer/"><span class="15" style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">肺癌</font></span></span></span></span></span></span></span></a><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">突变。</font></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><img alt="" src="../upload/64a7da6f1fd91295410649.jpg" style="width: 800px; height: 595px;" /></font></span></span></span></span></span></span></span></span></span></p>

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