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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><a href="http://www.india-drugstore.com/p/wenda_detail.php?id=2017&art_cate_value=0&art_navid_value=2"><span style="color:#3498db;"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑"><strong><span style="background-color:#f1c40f;">Mobocertinib TAK-788莫博替尼</span></strong></font></span></span></span></span></a><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">，在服用莫博替尼前，检测患者的</font>QTc间期、心电图和血清中电解质。服用莫博替尼期间，定期检测QTc间期和血清中电解质。</span></span></span></span></span></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><font face="微软雅黑">如果患者有先天性</font>QTc间期延长、心脏疾病或电解质异常，增加检测频率。避免同服可延长QTc间隔的药物。避免与中效或强效CYP3A抑制剂同服。</span></span></span></span></span></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal">Mobocertinib安全性可控，最常见的治疗相关不良事件包括腹泻(90%)、皮疹(45%)、甲沟炎(34%)、恶心(32%)、食欲下降(32%)、皮肤干燥(30%)和呕吐(30%)。</span></span></span></span></span></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal">3级及以上TRAEs(≥5%)为腹泻(21%)。19例(17%)患者因AEs停药，最常见的导致停药AEs是腹泻(4%)和恶心(4%)。</span></span></span></span></span></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:12.0000pt"><span style="background:#ffffff"><span style="font-family:微软雅黑"><span style="color:#000000"><span style="letter-spacing:0.0000pt"><span style="text-transform:none"><span style="font-style:normal"><img alt="" src="../upload/655c5fc9761bf909039743.jpg" style="width: 200px; height: 267px;" /></span></span></span></span></span></span></span></span></span></p>

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